![]() ![]() Sepm'ate sources o f error does not adversely affect parameter estimates. ![]() Simulation results for this case suggest that ignoring these The first model acknowledges two separate sources of residual error, replicationĮrror plus pure residual (assay) error. We have simulated three complexĮrror structures. ![]() Sources, with potentially other properties, should be considered. Often is only a minor part o f the difference between predicted and observed concentrations, other Residual error models, traditionally used in population pharmacokinetic analyses, have been developed as i f all sources o f error have properties similar to those o f assay error. Received February 2, 1994-Final November 30, 1995 Journal o f Pharmacokinetics and Biopharmaceutics, Vol. ![]()
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